Understanding Guillain-Barré Syndrome By Zero To Finals

hi this is Tom from Jared finals. Come in this video I’m going to be going through Gillian Barre syndrome and you can find me tonight’s on this topic at 30 finals.com Gillian Paris or in the neurology section of the 02 finals medicine book

restroom straighten

remember Ray syndrome is an acute paralytic polyneuropathy and it affects the peripheral nervous system and it causes an acute meaning quite quick onset symmetrical affecting both sides equally ascending weakness so it’s weakness that is coming up from the feet up Woods

it can also affect the sensory nerves causing a sensory neuropathy

is usually triggered by an infection and is particularly associated with gastroenteritis caused by campylobacter jejuni

or infection with cytomegalovirus or Epstein-Barr virus

what’s the pathophysiology to occur due to a process called molecular mimicry and this is where the B cells of the immune system create antibodies against the antigens on the pathogen that closing the preceding infection so they put a compilot back to gastroenteritis the B cells of the immune system create antibodies in games that can put it back.

and these antibodies oh so much proteins on the nerve cells they may Target proteins on the myelin sheath of the moat enough

or on the nerve axon itself

this damage to the nerve cells because of these antibodies against the nerve cells create the neuropathy and the symptoms

how does Gillian Barre Syndrome present

but it presents with asymmetrical ascending weakness which starts from the feet and moves out the body that will be reduced reflexes because it’s a peripheral neuropathy the maybe pray for loss of sensation on your pathic pain

and it may progress to the cranial nerves and cause a facial nerve weakness as well

what’s the clinical course

the symptoms usually start with in 4 weeks of the preceding infection of the Mets and your exams have had a gastroenteritis for a week previously the symptoms typically start in the feet and progressed outwits the symptoms Peak within two to four weeks and then there’s a slow recovery. That could last months to years

how do you make a diagnosis with a diagnosis of Gillian Beret syndrome is made clinically there’s no specific test that confirms the definitive diagnosis

ASM criteria to the Brighton criteria that can be used for a diagnosis and it can be supported by investigations such as nerve conduction studies which show reduce signal throughout the net

lumbar puncture to test the mysterious F and then your exams 2csf of somebody with Guillain-Barre he might have raised protein with a normal cell count and normal glucose

that’s about the management of Jillian Barberie

and v i v a Munich Club villains

plasma exchange to try remove some of those antibodies

supportive care to make sure the patient is still well despite having the associated weakness and importantly they need Venus form of embolism prophylaxis so maybe late molecular weight Heparin or an ox apparent to prevent them from developing blood clots because pulmonary embolism is a leading cause of death in Guinea Barre syndrome

in very severe cases weather tree spiritually failure than the patient’s mated intubation ventilation and admission to the Intensive Care Unit

final scores for the prognosis is a rough numbers but around 80% of people will fully recover 15% will be left with some sort of neurological disability may be some slight weakness or some neuropathy pain and 5% of patients will actually die from the condition

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